missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. Tocris Bioscience™ MTK 458

Tocris Bioscience™ MTK 458
GREENER_CHOICE

Product Code. 18004822
Click to view available options
Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
This item is not returnable. View return policy

Product Code. 18004822

Brand: Tocris Bioscience™ 7980/50

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

PINK1 activator

MTK 458 is a brain penetrant PTEN-induced kinase 1 (PINK1) activator. It binds to and stabilizes the active form of PINK1, increasing its activity and activating mitophagy downstream. It mediates clearance of pathogenic α-synuclein and normalizes pS65-Ubiquitin (pUb) in in vivo Parkinson's models. MTK458 is orally bioavailable.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material N-[(1R)-1,2,3,4-Tetrahydro-1-naphthalenyl]-6-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CAS 2499962-58-0
Quantity 50 mg
Target PINK1
Molecular Formula C17H15F3N4
Purity 0.98
Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Thank You! Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.