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Tocris Bioscience™ NICE 01

Product Code. 18004932
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5 mg
Unit Size:
5mg
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Product Code. 18004932 Supplier Tocris Bioscience™ Supplier No. 8088/5

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492.20 EUR valid until 2026-03-31
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Description

Heterobifunctional compound for nuclear import of FKBPF36V tagged proteins

NICE 01 is a bifunctional molecule consisting of (+)-JQ1 (Cat. No. 4499) and AP 1867 (Cat. No. 6207), with a PEG2-diamine linker. It has a high affinity (Kd = 94 pM) for FKBPF36V tagged proteins. It can induce nuclear localization of cytosolic proteins and target transcriptional regulation. It can be used to calculate the kinetic constant and passive diffusion across the nuclear pore.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material (R)-1-(3-((14-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-2,13-dioxo-6,9-dioxa-3,12-diazatetradecyl)oxy)phenyl)-3-(3,4-dimethoxyphenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-
Quantity 5 mg
Target Protein Dimerizers
Molecular Formula C63H76ClN7O13S
Purity 98%
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