OCT3/4 Rat anti-Human, Mouse, PE, Clone: EM92, eBioscience™
Rat Monoclonal Antibody
Marque: Affymetrix eBioscience 12-5841-80
Informations supplémentaires : Poids : 0.25000kg
DescriptionThis antibody can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser. Filtration: 0.2 μm post-manufacturing filtered. POU5F1, also commonly known as Oct-4, is a maternally expressed octamer-binding protein that was the first transcription factor described for the early stages of development. The role of POU5F1 in embryonic development suggested that it might be useful in the creation of stem cells that might be useful in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing POU5F1 and the transcription factors Sox2, Klf4 and Lin28 along with c-Myc in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing POU5F1, Sox2, KlfF4 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine.
|PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2|
|Octamer-binding transcription factor 3 antibody, Oct-3, OCT3, POU domain class 5 transcription factor 1 antibody, Oct-4, OTF3 antibody.|
|4° C, store in dark, DO NOT FREEZE!|
For Research Use Only.