missing translation for 'onlineSavingsMsg'
Learn More
Learn More
Invitrogen™ Ovine IL-17A ELISA Kit
Sandwich ELISA Kit
Brand: Invitrogen™ ESH3RBX10
Additional Details : Weight : 2.50000kg
Description
Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. IL-17A is a 32 kDa long, disulfide-linked homodimer consisting of 136 amino acids that is a member of a six-species family of proteins (IL-17A-17F) and signals through the IL-17 receptor (IL-17R/CDw217). High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells, and IL-17A also enhances expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts. In particular, human IL-17A also stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2. In the presence of human IL-17A, fibroblasts can sustain the proliferation of CD34+ hematopoietic progenitors and induce maturation into neutrophils. Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse receptor. IL-17A regulates the activities of NF-kappa B and mitogen-activated protein kinases, stimulates the expression of IL-6 and cyclooxygenase-2 (PTGS2/COX-2), and enhances the production of nitric oxide (NO).Specifications
Q13316 | |
0.45 pg/mL | |
ELISA | |
Colorimetric Microplate Reader | |
IL17A | |
<10% | |
HRP | |
RUO | |
2°C to 8°C | |
1 hr 20 min |
0.45 to 100 pg/mL | |
Biotin | |
Plasma, Serum, Supernatant | |
101103931 | |
<12% | |
Pre-coated 96 well plate|Standard|Assay Diluent concentrate|Biotinylated Detection Antibody|SAV-HRP|Wash Buffer|Chromogen|Stop Solution|Adhesive Plate Covers | |
10 x 96 Tests | |
Plasma, 50 μL|Supernatant, 50 μL|Serum, 50 μL | |
IL-17 A | |
4 hr 45 min |