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  5. Tocris Bioscience™ PHA 767491 hydrochloride

Tocris Bioscience™ PHA 767491 hydrochloride
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Product Code. 18015322
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18015322 10 mg 10mg
18085002 50 mg 50mg
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Product Code. 18015322 Supplier Tocris Bioscience™ Supplier No. 3140/10

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164.90 EUR valid until 2026-03-31
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Description

MK2 inhibitor; also cdk inhibitor; potently inhibits cdk9

ATP-competitive cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 0.034 - 0.75, 0.24 - 1.2, 0.25 - 1.1 and 0.46 - 1 μM for cdk9, cdk2, cdk1 and cdk5, respectively). Also inhibits mitogen-activated protein kinase-activated protein kinase-2 (MK2; IC50 = 171 nM). Prevents initiation of DNA replication. Inhibits cell proliferation in a variety of human cell lines and induces apoptosis in a p53-independent manner in vivo.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 942425-68-5
Molecular Formula C12H12ClN3O

Specifications

Quantity 10 mg
Formula Weight 249.7
Purity >99%
Molecular Weight (g/mol) 249.698
Chemical Name or Material PHA 767491 hydrochloride
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