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Phleomycin, Fisher BioReagents

Catalog Number 10319787
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Quantity:
100 mg
Packaging:
Plastic Bottle
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Disrupts the integrity of DNA, and blocks S-phase entry in the cell cycle

  • An antibiotic often used as selection agent to determine transformation efficiency of algae, fungi, and mammalian cells
  • Serves as a selection agent for transformed cells carrying the antibiotic-resistance gene Sh ble
  • Causes DNA fragmentation by introducting double-strand breaks in DNA and prevents cells from entering S-phase during the cell cycle
TRUSTED_SUSTAINABILITY
Type Phleomycin
Physical Form Liquid
Absorbance 0.75 to 1.05 AU at 244nm
CAS 11006-33-0
Source Streptomyces verticillus
Molecular Formula C51H75N17O21S2
Odor None
Packaging Plastic Bottle
InChI Key QRBLKGHRWFGINE-UGWAGOLRSA-N
SMILES CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O)(C)OC4C(C(C(C(O4)CO)O)(C(=O)N)O)O)C(=O)NC(C)C(C(C)C(=O)NC(C(=O)C)C(=O)NCCC5=NC(CS5)C6=NC(=CS6)C(=O)N)O
IUPAC Name 2-[2-[2-[[2-[[4-[[2-[[6-amino-2-[3-amino-1-[(2,3-diamino-3-oxopropyl)amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[(2R,3S,4S,5S,6S)-3-[(2S,3R,4R,5S)-4-carbamoyl-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)-
Molecular Weight (g/mol) 1326.379
PubChem CID 72511
Formula Weight 1526.5
Sterile Filtered Pass Test
Quantity 100 mg
Chemical Name or Material Phleomycin
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Safety and Handling

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Product Identifier
  • Phleomycin, 2% solution in water
 Signal Word
  • Warning
 Hazard Category
  • Carcinogenicity Category 2
  • Respiratory sensitiser Category 1
 Hazard Statement
  • H351-Suspected of causing cancer.
  • H317-May cause an allergic skin reaction.
 Precautionary Statement
  • P201-Obtain special instructions before use.
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P308+P313-IF exposed or concerned: Get medical advice/attention.
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