Invitrogen™ Rat Ghrelin (aa 252-267) Synthetic Peptide

GHRL encodes ghrelin-obestatin preproprotein, which generates ghrelin and obestatin. Ghrelin is an the ligand for the growth hormone secretagogue receptor type 1 and is involved in regulating growth hormone release. Ghrelin has an appeptite-stimulating effect and induces adiposity and stimulates gastric acid secretion. Obestatin may be the ligand for the orphan G protein-coupled receptor GPR39 and is involved in satiety and can have an appetite-reducing effect resulting in decreased food intake. PEP-290 is a 23 amino acid synthetic peptide whose sequence is derived from the rat Obestatin. The sequence of this peptide is (amino to carboxy terminus): F-N-A-P-F-D-V-G-I-K-L-S-G-A-Q-Y-Q-Q-H-G-R-A-LThis peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product, Obestatin, catalog &Num; PA1-1070. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (∽70-fold) for competitive inhibition of antibody-protein binding reactions.Reconstitute with 0.1 mL of distilled water.