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GeneBLAzer™ RXRα-UAS-bla HEK 293T Cells
GeneBLAzer™ RXRα-UAS-bla HEK 293T Cells contain the ligand-binding domain (LBD) of the human retinoid X receptor-alpha (RXR alpha) fused to the DNA-binding domain of GAL4.
Brand: GeneBLAzer™ K1697
Additional Details : Weight : 0.01000kg
Description
- RXR alpha-UAS-bla HEK 293T cells contain the ligand-binding domain (LBD) of the human retinoid X receptor-alpha (RXR alpha) fused to the DNA-binding domain of GAL4 stably integrated in the GeneBLAzer™UASbla HEK 293T cell line.
- GeneBLAzer™UAS-bla HEK 293T cells stably express a betalactamase reporter gene under the transcriptional control of an upstream activator sequence (UAS).
- When an agonist binds to the LBD of the GAL4 (DBD)-RXR alpha (LBD) fusion protein, the protein binds to the UAS, resulting in expression of alpha-lactamase.
- Division Arrested (DA) cells are available in two configurations- an Assay Kit (which includes cells and sufficient substrate to analyze 1 x 384-well plate), and a tube of cells sufficient to analyze 10 x 384-well plates. RXR alpha-UAS-bla HEK 293T cells are functionally validated for Z' and EC50 concentrations of 9-cis-retinoic acid.
- In addition, RXR alpha-UAS-bla HEK 293T cells have been tested for assay performance under variable conditions, including DMSO concentration, cell number, stimulation time, and substrate loading time (data available upon request).
Specifications
| Dry Ice Storage -80°C/Liquid Nitrogen | |
| Fluorescent | |
| RXR alpha-UAS-bla HEK 293T cells (K1261) | |
| Dividing Cells |
| Antagonist: Spironolactone; Primary Agonist: Aldosterone | |
| Nuclear Receptors | |
| 2 x 106 Cells |