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SIGLEC H Rat anti-Mouse, PE, Clone: eBio440c, eBioscience™

Rat Monoclonal Antibody

Marque:  Affymetrix eBioscience 12-0333-80

Informations supplémentaires : Poids : 0.25000kg

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Code produit. 15288509

  • 126.00€ / 25µg


Date dexpédition estimée
du fournisseur 22-08-2019
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Description

Description

Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser. Filtration: 0.2 μm post-manufacturing filtered. Siglec-H, a protein exclusively found on pDC (plasmacytoid dendritic cells) or type I IFN-producing cells (IPC) in the naive mouse. Mouse IPC are typically PDCA+, CD11c+, CD11b-, B220+, and Ly-6C+, and are quick to respond to viruses. Siglec-H is a transmembrane protein of the Ig superfamily that like CD33 have been shown to bind sialic acid but lacks the characteristic cytoplasmic ITIM domain (immunoreceptor tyrosine based inhibitory motif). To overcome the lack of a cytoplasmic domain, Siglec-H associates with DAP12 thereby allowing for signal transduction. The eBio440c antibody has been shown to inhibit pDC function (inhbits IFNalpha secretion in response to CpG). It has been observed that some mouse strains (such as SJL) have higher percentages of pDCs compared to C57BL/6.
Spécification

Spécification

Siglec H
Monoclonal
0.2 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
Liquid
Siglech
IgG2b, kappa
25 μg
4° C, store in dark, DO NOT FREEZE!
Primary
233274
Flow Cytometry
eBio440c
PE
Siglech
Sialic Acid-Binding Immunoglobulin-Like Lectin H; SiglecH
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
Vidéos
Documents

For Research Use Only.