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Thermo Scientific™ Tango™ MTNR1A-bla U2OS Cells

Product Code. 10450174
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Quantity:
8 x 106 cells
Unit Size:
Each
Product Code. Quantity unitSize
10450174 8 x 106 cells Each
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Product Code. 10450174

Brand: Thermo Scientific™ K1669

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Description

The Tango™ MTNR1A-bla U2OS cells contain the human Melatonin Receptor 1A (MTNR1A) linked to a TEV protease site and a Gal4-VP16 transcription factor stably integrated into the Tango™ GPCR-bla U2OS parental cell line.

This parental cell line stably expresses a beta-arrestin/TEV protease fusion protein and the beta-lactamase (bla) reporter gene under the control of a UAS response element.

The Tango™ MTNR1A-bla U2OS cells have been functionally validated for Z' factor and EC50 concentrations of established ligands. In addition, Tango™ MTNR1A-bla U2OS cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary for each product.

TRUSTED_SUSTAINABILITY

Specifications

Accession Number NM_005958.3
Assay Entry Cell-based beta-arrestin recruitment
Cell State Dividing Cells
Content And Storage K1669 Tango™ MTNR1A-bla U2OS cells
(LiveBLAzer™-FRET B/G Loading Kit, Solution D and other materials are required separately; please refer to the protocol).
Includes:
• Tango™ MTNR1A-bla U2OS cells
• Tango™ MTNR1A-bla U2OS Assay Protocol
• Certificate of Analysis
The Tango™ MTNR1A-bla U2OS cells are shipped on dry ice and should be stored in liquid nitrogen immediately upon receipt.
Cytoplasmic Tail Native Tail
Detection Method Fluorescence
Gene Symbol MTNR1A
Population Status Single Cell Clone Origin
Product Line GeneBLAzer
Protein Family GPCR (G-Protein Coupled Receptors)
Quantity 8 x 106 cells
Readout End Point
Reporter Gene BLA (Beta-Lactamase)
Target Entry MTNR1A
Cell Line U2OS
System Type Tango™
Druggable Target GPCR
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For Research Use Only. Not for use in diagnostic procedures.

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