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Thymidylate Synthase Ab-1, Mouse Monoclonal Antibody,Lab Vision™ Epredia™
Provide accurate, reproducible results Epredia™ Thymidylate Synthase Ab-1, Mouse Monoclonal Antibody.
154.02€ - 734.40€
Specifications
| Antigen | Thymidylate Synthase Ab-1 |
|---|---|
| Clone | TS 106 |
| Applications | Flow Cytometry, Immunofluorescence, Immunoprecipitation, Western Blot |
| Classification | Monoclonal |
| Conjugate | Unconjugated |
| Product Code | Brand | Concentration | Quantity | Price | Quantity & Availability | ||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Concentration | Quantity | Price | Quantity & Availability | ||||
|
12681537
|
Epredia
MS-471-P1 |
200μg/mL | 500 μL |
448.00€
500µL |
Estimated Shipment: 13-06-2024 Log in to see stock. |
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|
12671537
|
Epredia
MS-471-P0 |
200μg/mL | 100 μL |
This item has been discontinued and is no longer available. View the product for possible alternatives or contact our Technical Support team on 056 260 260 for assistance. |
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|
12661537
|
Epredia
MS-471-P |
200μg/mL | 1 mL |
This item has been discontinued and is no longer available. View the product for possible alternatives or contact our Technical Support team on 056 260 260 for assistance. |
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|
12691537
|
Epredia
MS-471-P1ABX |
1mg/mL | 100 μL |
This item has been discontinued and is no longer available. View the product for possible alternatives or contact our Technical Support team on 056 260 260 for assistance. |
|||||
|
12601547
|
Epredia
MS-471-PABX |
1mg/mL | 200 μL |
This item has been discontinued and is no longer available. View the product for possible alternatives or contact our Technical Support team on 056 260 260 for assistance. |
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Description
Thymidylate Synthase (TS) (EC 2.1.1.45) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.Host Species: Mouse
Clone: TS 106
Isotype: IgG1/κ
Species Reactivity: Human. Others not known.
Epitope: Not determined
Immunogen: Recombinant human TS enzyme
Molecular Weight: 36kDa
Positive Control: 5-FU-resistant cell cancer lines or colon CA
Cellular Localization: Nuclear and cytoplasmic
Recommended for:
- Western Blotting
- Immunofluorescence
- Immunoprecipitation (Native verified)
- ELISA
- Flow Cytometry
Note:
USA: RUO; Int'l: RUO
Specifications
| Thymidylate Synthase Ab-1 | |
| Flow Cytometry, Immunofluorescence, Immunoprecipitation, Western Blot | |
| Unconjugated | |
| Mouse | |
| DNA Repair | |
| Recombinant human TS enzyme | |
| Primary |
| TS 106 | |
| Monoclonal | |
| Concentrated | |
| RUO | |
| Human | |
| IgG2a κ |