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Tocris Bioscience™ TM2 TEAD inhibitor

Potent and reversible inhibitor of TEAD mediated Hippo/Yap signalling

156.58€ - 588.54€

Specifications

Chemical Name or Material 4-[3-(2-Cyclohexylethoxy)benzoyl]-N-phenyl-1-piperazinecarboxamide
CAS 1008768-41-9
Target YAP1
Molecular Formula C26H33N3O3
Purity 0.98
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Product Code Brand Quantity Price Quantity & Availability  
18706075
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Tocris Bioscience™
7917/10
10 mg
156.58€
10mg
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Estimated Shipment: 22-07-2024
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18705925
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Tocris Bioscience™
7917/50
50 mg
588.54€
50mg
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Estimated Shipment: 22-07-2024
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Description

Description

TM2 TEAD inhibitor is a potent and reversible TEA domain transcription factor inhibitor (IC50 = 38 nM and 156 nM for TEAD4 auto-palmitoylation and TEAD2 palmitoylation, respectively). It inhibits TEAD-YAP association and transcriptional activity. TM2 TEAD inhibitor exhibits strong antiproliferation effects as a single agent or in combination with a MEK inhibitor in YAP-dependent cancer cells. Also inhibits YAP-dependent liver organoid growth ex vivo.
Specifications

Specifications

4-[3-(2-Cyclohexylethoxy)benzoyl]-N-phenyl-1-piperazinecarboxamide
YAP1
0.98
1008768-41-9
C26H33N3O3
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