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Tocris Bioscience™ UNC 6934
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Product Code. 18726186
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 18726186

Brand: Tocris Bioscience™ 7183/50

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This item is not returnable. View return policy

Description

Antagonizes PWWP1 interaction with nucleosomal H3K36me2, alters NSD2 nucleolar localization

UNC 6934 binds to the N-terminal proline-tryptophan-tryptophan-proline (PWWP) domain of nuclear receptor-binding SET domain-containing 2 (NSD2). UNC 6934 inhibits PWWP1 interaction with nucleosomal H3K36me2 (IC50 = 104 nM) by occupying the canonical H3K36me2-binding pocket of PWWP1. It selectively binds endogenous NSD2 in cells and causes accumulation of endogenous NSD2 in the nucleolus.
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Specifications

Chemical Name or Material N-Cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]-2H-1,4-benzoxazine-7-carboxamide
CAS 2561494-77-5
Quantity 50 mg
Target Lysine Methyltransferase Inhibitors
Molecular Formula C24H21N5O4
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