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TCR V alpha 2, eFluor 450, clone: B20.1, eBioscience™

Rat Monoclonal Antibody

Marque:  Affymetrix eBioscience 48-5812-80

Informations supplémentaires : Poids : 0.25000kg

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Code produit. 15361790

  • 90.50€ / 25µg


Date dexpédition estimée
du fournisseur 24-04-2019
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Description

Description

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.
Spécification

Spécification

TCR V alpha 2
Monoclonal
0.2 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
TCRVA; TCRVA2; V alpha 2; V alpha-2 TCR; Valpha 2; Valpha2; Va 2; Va2
IgG2a, lambda
25 μg
4° C, store in dark, DO NOT FREEZE!
Primary
Mouse
Flow Cytometry
B20.1
eFluor® 450
Liquid
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Vidéos

For Research Use Only.