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  5. Tocris Bioscience™ VH 032

Tocris Bioscience™ VH 032
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Product Code. 18756115
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Product Code. 18756115 Supplier Tocris Bioscience™ Supplier No. 7774/10

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Description

Inhibitor of VHL; blocks interaction of VHL and HIF-α

VH 032 is an inhibitor of E3 ubiquitin ligase VHL (Kd = 185 nM). Blocks interaction between VHL and HIF-α downstream of HIF-α hydroxylation, initiating hypoxic response. VH 032 treatment causes dose dependent upregulation of HIF-target genes including CA9, GLUT1 and PHD2 in different cell lines. Cell permeable.
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Specifications

Chemical Name or Material (2 S,4 R)-1-(-2-Acetamido-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
CAS 1448188-62-2
Quantity 10 mg
Target Von Hippel Lindau
Molecular Formula C24H32N4O4S
Purity 0.98
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