missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. STEMCELL Technologies XAV939

STEMCELL Technologies XAV939

Product Code. 17180102
Encompass_Preferred
Change view
Click to view available options
Quantity:
1 mg
10 mg
Unit Size:
10mg
1mg
2 product options available for selection
Product selection table with 2 available options. Use arrow keys to navigate and Enter or Space to select.
Product Code. Quantity unitSize
17180102 10 mg 10mg
17170102 1 mg 1mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 2 options available.
2 options
This item is not returnable. View return policy
Product Code. 17180102 Supplier STEMCELL Technologies Supplier No. 72674

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

WNT pathway inhibitor; Inhibits TNKS1 and TNKS2

  • XAV939 is a potent, small molecule inhibitor of tankyrase (TNKS) 1 and 2 (IC50 = 11 and 4 nM, respectively) (Huang et al.) By inhibiting TNKS activity, XAV939 increases the protein levels of the axin-GSK3β complex and promotes the degradation of β-catenin in SW480 cells (Huang et al.), thereby inhibiting WNT pathway downstream actions
  • Induces cardiomyogenesis in mesoderm progenitor cells derived from mouse embryonic stem cells (Wang et al.)
  • In combination with the SMAD inhibitors LDN193189 and SB431542, promotes induction of forebrain fates in human pluripotent stem cell lines (Maroof et al.)
  • Inhibits colony formation of APC-deficient, β-catenin-dependent DLD-1 colorectal cancer cells (Huang et al.)

Specifications

CAS 284028-89-3
Quantity 10 mg
Molecular Formula C14H11F3N2OS
Purity ≥98%
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.