The expansion and maintenance of stem cells requires careful attention to culture conditions to enable successful results. Find robust and reliable media, supplements and reagents, matrices, freezing solutions, cell culture plastics, and instruments to support healthly growth and expansion of your stem cells.
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Engineering stem cells is crucial to analyzing disease pathways, better understanding of gene and protein expression, and studying differentiation. Manipulate your cells efficiently for downstream applications with reprogramming and gene editing tools.
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Confirming pluripotency or determining the utility of cells in downstream experiments is a prerequisite in stem cell research. Whether analyzing proliferation, protein levels, gene expression, or epigenetic profiles, we have the right instruments and products for your research. Choose from among our wide range of cellular and molecular tools for your stem cell analysis.
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Stem cell differentiation requires standardized culture methods to ensure reproducible and reliable results. The Fisher Scientific channel provides you with an easy-to-use, flexible set of tools for targeted differentiation to your desired cell lineage. Simplify your workflow with our stem cell differentiation products.
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We offer a wide range of solutions to help you achieve your cell therapy goals. Our extensive portfolio of xeno-free and animal origin–free media, reagents, and equipment are designed to enable clinical and commercial cell therapy manufacturing according to good manufacturing practice (GMP) guidelines. Find the best solutions that support your stem cell therapy needs.
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We offer a wide range of safety solutions to protect your employees and facilities from hazards and your samples from contamination.
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The rapid increase in stem cell research in recent years reflects the high interest in stem cells. Researchers hope stem cell studies can help to increase the understanding of how diseases occur, generate healthy cells to replace affected cells (regenerative medicine) or test new drugs for safety and effectiveness.
Building on the results of this basic research, a new research discipline called "translational research" has emerged to develop new therapies. Stem cell therapy uses stem cells to promote the repair response of diseased, dysfunctional or injured tissue. It represents the next chapter in organ transplantation and uses cells in place of donor organs, which are in limited supply. Whether you are involved in stem cell research, developing a stem cell-based therapy or testing new drugs using stem cells, we can offer a complete portfolio of stem cell research products and tools from leading manufacturers that simplify your workflow and enable the continuity, efficiency, and precision that drive discovery.
Stem cells are cells from which all other cells with specialized functions arise. Unlike differentiated cells such as nerve cells, skin cells, heart muscle cells and blood cells, stem cells have the potential to develop into one, several or all of the body's differentiated cell types, depending on the type of stem cell. No other cell in the body has the natural ability to generate new cell types.
Multipotent stem cells can produce a variety of differentiated cell types, but not all cell types of the adult body. Examples of multipotent stem cells are the hematopoietic stem cells and mesenchymal stromal cells (MSCs). Hematopoietic stem cells can generate all cell types of the blood such as erythrocytes and lymphocytes, but not other cell types such as heart muscle cells or nerve cells. MSCs can be differentiated to chondrocytes, osteocytes, or adipocytes by using specific growth factors.
Stem cell therapy, also known as regenerative medicine, promotes the repair response of diseased tissue using stem cells or their derivatives. Researchers grow stem cells in a lab and these stem cells are manipulated to differentiate into specific types of cells, such as heart muscle cells, blood cells or nerve cells. The differentiated cells can then be implanted into a person. Currently, several stem cell-based therapies utilizing adult stem cells are clinically available and mainly include bone marrow transplants of hematopoietic stem cells and skin grafts for severe burns.
There are various types of stem cells: pluripotent, multipotent, and unipotent.
Pluripotent stem cells are embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs). They can divide into more stem cells or can become any type of cell in the body and can be used to regenerate or repair diseased tissue and organs. However, ESCs are derived from embryos and therefore research using human embryonic stem cells is ethically controversial. In some countries, such as Germany, even the production of new ESCs is prohibited. A very promising alternative to embryonic stem cells is induced pluripotent stem cells (iPSCs). They are obtained by the “reprogramming” of adult cells, e.g. connective tissue cells from the skin, through the introduction of some genes that are very active during early embryonic development.
For these cells, scientists need a serum-free medium with controlled amounts of growth factors to keep cells undifferentiated for as long as possible. In addition, scientists must add an attachment matrix or carrier to the culture to allow the cells to expand.
