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Thermo Scientific Connected Chromatography Solutions


Sample Preparation


Your sample is precious and you cannot afford failures. The Thermo Scientific™ portfolio includes a comprehensive range of products designed to deliver clean and consistent extractions using innovative sample preparation technologies for your analytical needs.

SOLA and SOLAμ SPE

This first fritless SPE product range which has been specifically designed for bioanalysis provides greater reproducibility with cleaner, more consistent extracts. Thermo Scientific SOLA™ products provide unparalleled performance characteristics compared to conventional SPE, phospholipid removal and protein precipitation products.

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SMART Digest Kits

Designed for biopharmaceutical and proteomic applications that require highly reproducible, sensitive and fast analyses of proteins, often in high-throughput workflows.

Learn more about Smart Digest Kits.

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Titan3 Syringe Filters

Providing cleaner sample extracts by removing interfering materials and fine particles. Delivering high-quality, robust filtration products for a wide range of samples and applications.

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LC and GC Columns and Solvents

The Thermo Scientific brand has been a leader in LC and GC column technologies for over 40 years. You can be confident in the quality of Thermo Scientific products, including the latest and most comprehensive range of innovative columns and accessories for HPLC, UHPLC and GC techniques.

Accucore Core-Enhanced Technology

Solid-core particles enable high-speed, high-resolution separations with back pressures significantly lower than those associated with UHPLC.

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TraceGOLD GC Columns

The premium standard in GC column performance, TraceGOLD™ GC Columns deliver low-bleed, excellent reproducibility and high levels of inertness.

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UHPLC-MS Solvents

Thermo Scientific ultra-high-purity solvents are designed to deliver the highest sensitivity, ensure low formation of metal ion adducts, and improve peak profiles.

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EasySpray LC Columns

Ensure robust nano and capillary flow with an integrated design that eliminates dead volume and is temperature-controlled for maximum reliability and performance.

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BioLC Columns & Accessories

The analysis of biomolecules demands a range of sample separation modes, column chemistries and column configurations. Thermo Scientific polymeric and silica columns in analytical and nano-scale formats are designed to handle these challenging separations.

AAV- Gene Therapies: SurePac™ Bio 550 SEC MDi™

Maximize efficiency and minimize interactions with our innovative MDi™ tech to optimize aggregate analysis of AAVs.

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Oligonucleotides: DNAPac RP

Superior resolution and separation of oligonucleotides, including double-stranded (ds) DNA/RNA fragments.

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Charged Variants: MAbPac SCX-10

Quickly and easily target a wide range of antibodies and their charged-state variants using MAbPac SCX-10.

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pH Gradient Buffers: CX-1 A&B

Simple to optimise and easily automated to obtain fast and highly robust, reproducible HPLC gradients.

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SureSTART™ Performance Levels


Level 1: General Purpose Applications

If you are verifying compound presence and performing quantification using detection techniques such as UV, RI and FID, our Performance Level 1 products are the perfect solution for you – select the products with the one wave.

Level 1 – Vials and Caps

Level 2: High Throughput Applications

Get the performance you need to deliver high quality data with an uninterrupted workflow.

SureSTART Level 2 vials have very low metal contents and leachables to ensure that they conform to the high standards you need to meet your regulatory requirements. The septa are conditioned to provide a very low level of chromatographic extractables. These products support routine analyses and deliver high quality data with an uninterrupted workflow.

Level 2 – Vials and Caps
Level 2 – Headspace Vials and Caps

Level 3: High Performance Applications

Protect your most valuable samples and deliver consistent, reproducible results for your most demanding analyses.

SureSTART Level 3 products are packed in a clean environment according to our own hygiene concept and regulations to protect against contaminating factors. The vials contain the lowest levels of extractable metals and leachables to ensure consistent, reproducible sensitivity and selectivity for the most challenging analytes. The septa are conditioned to provide the lowest level of chromatographic extractables. Choose these products for ultimate method performance and high levels of sample security and integrity.

Level 3 – Vials and Caps
Level 3 – Gold-Grade Vials and Inserts
Level 3 – Crimp Top and Screw Top Microvials and Caps for <2 mL Samples
Level 3 – Snap Top Microvials and Caps for <2 mL Samples
Level 3 – Headspace Vials and Caps

Manual Crimpers and Decrimpers


Achieve secure, repeatable crimps or remove seals with minimized risk of damage.

Use Thermo Scientific™ SureSTART™ vial crimpers and decrimpers to manually attach or remove crimp caps from vials, respectively. These manual crimpers and decrimpers are available in 8 mm, 11 mm, 13 mm and 20 mm sizes, and allow you to easily seal or remove crimp caps reliably.

Manual Tools

Red Manual Crimper
Black Manual Decrimper

Electronic Crimpers and Decrimpers


Our electronic Thermo Scientific™ crimper portfolio includes tools for 8 mm, 11 mm, 13 mm, and 20 mm crimp caps. The tools provide all important settings like actual crimp power at one glance. The hand-held crimpers and decrimpers allow crimping of vials with aluminium, pressure release and bi-metal caps while remaining in most sample trays.

The crimp head selection also includes special crimp heads for 13 mm and 20 mm flip-off caps, additional special heads are available on request. Simple, one-handed operation allows you to attach or remove crimp vial seals with high sample security.

Electronic Tools Portfolio

Black Electronic Hand-Held Battery-Operated Crimper: Generation 4
Black Electronic Hand-Held Battery-Operated Decrimper: Generation 4
Black Electronic Crimper for FTFO and Flip-Off Crimp Caps: Generation 4
Black Electronic High-Power Programmable Crimp Station: Generation 2
Electronic High-Power Programmable Crimper Kits

SureSTART Certified Vial and Cap Kits

MSCERT+


MSCERT+ kits: Certified high-performance kits for use with mass spectrometry - with an additional level of security. In addition to all the quality checks that are performed for the MSCER line, the MSCERT+ range is pre-cleaned to provide the lowest ion content and particulate levels in the vial to protect sample integrity; guaranteeing there is no dirt or dust from manufacturing present which might clog up your GC or LC column and affect column lifetime and system performance. Highly recommended for direct injection analysis (DIA).

Featured Categories

Other Certified Kits


Other certified kits available include EPA-certified and TOC-certified ranges, as well as scintillation kits.

Featured Categories

WebSeal™ Performance Levels


Level 1: General Purpose Applications

If you are working in a non-regulated laboratory using water and polar solvents, our Performance Level 1 plastic, non-coated, non-sterile, chromatography tested well plates are the perfect solution for you.

96-Well Plates
Compatible With:
384-Well Plates
Compatible With:

Level 2: High Throughput Applications

If you are working in a regulated laboratory using water and polar solvents, our Performance Level 2 plastic, non-coated, non-sterile, GC-MS and LC-MS-tested well plates are the perfect solution for you.

96-Well Plates
Compatible With:
384-Well Plates
Compatible With:

Level 3: High Performance Applications

If you are working in a regulated laboratory using all solvents (including non-polar), our Performance Level 3 WebSeal Plate+ (unique glass-coated plastic plates) plates and glass inserts are the perfect solution for you.

96-Well Plates
Compatible With:
384-Well Plates
Compatible With:

Get Better Results While Saving Time and Labor

The right sample preparation solution can save you time and solvent, reduce repetitive functions, and provide consistency and accuracy of results. You’ll find the right solution among our broad selection of sample preparation consumables. Our most recent innovations include the Thermo Scientific™ SMART Digest™ kits for fast, highly reproducible protein digestion and the next generation SOLA™ solid phase extraction fritless SPE range, which provides higher levels of reproducibility and robustness compared to conventional devices.

Browse these products:

SOLA and SOLAμ SPE Cartridges and Plates

Award-winning fritless polymeric technology eliminates the issues encountered in conventional SPE. Available in a range of phases, formats, and sizes to suit any bioanalysis application.

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Dispersive SPE (QuEChERS)

These pre-prepared dispersives allow you to achieve accurate pesticide determinations in food and other complex matrices.

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SPE Plates

This comprehensive range of SPE plates delivers a new level of extract purity and reproducibly. They remove uncertainty and improve the quality, time and cost of analysis.

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SPE Cartridges

This broad range of SPE cartridges delivers a new level of extract purity and reproducibly. They remove uncertainty and improve the quality, time and cost of analysis.

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SPE Extraction Tips

Get fast SPE on volumes as low as 100nL using these revolutionary microscale tips. Choose from several popular chemistries.

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Syringe Filters

Remove interfering materials and fine particles from a wide range of samples to provide more consistent and reliable results using these high-quality, robust syringe filters.

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Solid Supported Liquid Extraction (SLE)

Obtain fast, effective removal of phospholipids from biological samples by SLE extraction, with considerable benefits over liquid/liquid extraction (LLE) protocols.

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Online SPE

Perform fast, effective clean up and concentration of target compounds online by using these SPE products with an appropriate HPLC column to retain specific analytes in a sample matrix.

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Protein Digestion

Simple, robust, reproducible and fast digestion of proteins is now possible with our SMART Digest™ kits. Use for highly sensitive and fast analyses in high throughput workflows.

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Protein Precipitation Plates

Remove proteins from biological compounds using the protein crash technique using these 96-well plates. The plates provide a high-throughput purification for µL to mL samples.

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Filter Plates

Choose from a wide range of chemistries in 96-well plate format to filter and clean up your small-scale biological samples.

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Lab Plates

Purify proteins, DNA, RNA and other biomolecules using these 96-well plates. Choose from a range of purification materials embedded at the bottom of each well.

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Digital Dispensers

Often used for dispensing volatile solvents, hazardous, corrosive or viscous chemicals, this dispenser is precise, accurate, and operator independent.

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MEPS Micro Extraction Packed Sorbent

Micro Extraction by Packed Sorbent (MEPS) offers fast sample preparation on low-volume samples. They can be used for high-throughput online GC and LC applications.

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SPE Manifolds and Accessories

These vacuum manifolds process multiple SPE, SLE or protein precipitation samples simultaneously in cartridge or plate format and a broad array of quality parts and accessories is available for our Thermo Scientific™ HyperSep™ vacuum manifolds.

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HPLC Columns for Characterizing Biopharmaceutical Molecules

BioLC Columns

Do you have a biological sample? Get high resolution, high efficiency separations from our unique chemistries that are specially designed for proteins, peptides, carbohydrates, nucleic acids, oligonucleotides and more.

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Gradient Buffers

The Thermo Scientific pH gradient platform accelerates method development and facilitates method transfer to QA/QC for a wide range of protein and mAb charge variants through a generic LC-based approach to charge variant characterization.

  • Patented buffer formulations enable fast, robust and reproducible pH gradients that are simple to optimize and easily automated
  • Ready to use with existing LC columns and systems, without the need for time consuming mobile phase adjustments
  • Applicable to the majority of mAb
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Acclaim PepMap Columns

The standard for peptide separations in proteomics.

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Analytical Columns

Quality columns you can rely on for quality results

Need a reliable column? With over 40 years as a leader in LC column technology, you can rely on the quality of Thermo Scientific™ HPLC and UHPLC columns. Our extensive family of products offers a variety of particle sizes and column designs to meet all separation needs, including improved resolution, enhanced sensitivity, faster analysis and consistent performance.

Hypersil Classical

For a robust, general-purpose column to use in a wide range of applications, choose Thermo Scientific™ Hypersil™ Classical.

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Accucore Columns

Solid-core particles enable high-speed, high-resolution separations with back pressures significantly lower than those associated with UHPLC.

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Hypersil GOLD™

Thermo Scientific™ Hypersil GOLD™ columns offer chromatographers outstanding peak shape for reversed phase, ion exchange, HILIC or normal phase chromatography.

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Acclaim

Acclaim columns are based on high-purity, porous silica particles with advanced and innovative column bonding technologies. This provides complementary selectivity, high column efficiencies and symmetrical peaks.

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Hypercarb

100% porous graphitic carbon for extended separation capabilities

Used for the retention and separation of highly polar species. Thermo Scientific™ Hypercarb™ columns are ideally suited to solve in both reversed phase and normal phase HPLC and LC-MS applications.

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Syncronis

Remarkable separations guaranteed time after time

Thermo Scientific™ Syncronis™ HPLC columns are used to achieve consistent, reproducible separations. Chemistries available for a variety of applications.

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Analytical Preparative Columns

Scale up to more options, columns in every format, media and size:


UHPLC-MS Solvents, Blends, Flush Solutions and Ready-to-Use Buffers

UHPLC-MS Solvents

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Thermo Scientific™ ultrapure solvents are designed to deliver the highest sensitivity, help ensure low formation of metal ion adducts and improve peak profiles.

UHPLC-MS Methanol

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Ammonium Formate (10mM), in Water with 0.05% Formic Acid

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Ammonium Formate (10mM), in Water with 0.05% Formic Acid

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LC-MS Mobile Phase Blends

Thermo Scientific™ LC-MS Mobile Phase Blends are suitable for detection of vitamin D2 and D3 by LC-MS.

Ammonium Formate (10mM), in Methanol with 0.05% Formic Acid

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Ammonium Formate (10mM), in Water with 0.05% Formic Acid

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ChromaCare LC-MS Biologics Flush Solution

ChromaCare LC-MS Flush Solution – clearing the way for interference-free chromatography. Thermo Scientific™ is pleased to introduce a family of solutions designed for both start-up and maintenance of sensitive LC-MS chromatographs.

Isopropanol Acetonitrile Acetone (9/9/2) Flush Solution, LCMS

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Gas Chromatography (GC) Columns

High temperature stability, low bleed and long lifetimes

Our columns represent a leap forward in performance, delivering low bleed and superior inertness. Select from our comprehensive portfolio of Thermo Scientific™ GC columns that meet all of your analytical needs and achieve reliable, reproducible results for your gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) applications.  

TraceGOLD™ Columns

Offering you a leap forward in GC capillary column performance delivering ultra low bleed, superior inertness and the highest levels of reproducibility guaranteed.

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UltraFAST GC Columns

Tailored for robustness and speed

If your laboratory processes large numbers of samples each day, Thermo Scientific™ TRACE™ GC UltraFast GC columns have the processing speed and throughput you need. These short, narrow-bore columns are designed for use with the TRACE UltraFast GC system to deliver a significant gain in analysis speed compared to conventional GC procedures.

Common applications:

  • Chemical
  • Petrochemical
  • Environmental
  • Flavors and fragrances
  • General purpose
  • Alcohols
  • Ketones
  • FAMEs
  • Volatiles
  • FFAP
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PLOT Columns

Guaranteed to deliver performance without particle release

Engineered for the analysis of both polar and nonpolar compounds, these Thermo Scientific™ GC columns incorporate a porous intermediate-polarity phase into the tubing walls with essentially no particle release thereby not only ensuring superior column performance and stability but also preventing damage to detection systems.

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GuardGOLD Capillary Columns

GuardGOLD™ Capillary Columns are specialized chromatography columns designed to protect analytical columns from contamination and extend their lifespan. These columns are typically used in gas chromatography (GC) and are known for their high efficiency and reliability. They offer:

  • Enhanced Protection: Guard columns trap contaminants and particulates, preventing them from reaching the analytical column
  • Extended Column Life: By protecting the main column, GuardGOLD™ columns help maintain performance and reduce the frequency of column replacements
  • High Performance: These columns maintain the integrity of the sample analysis, ensuring accurate and reproducible results
  • Ease of Use: Designed for easy installation and compatibility with various GC systems
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GC Accessories

GC Gas Filters

Use these Click On™ and SuperClean™ inline gas filters to improve gas quality and eliminate contaminants.

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GC Injection Port Liners and Accessories

Ensure reproducibility by using these injection liners for GC. They are highly deactivated and produced to exacting tolerances.

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GC Syringes

Manual and autosampler syringes can be used with Thermo Scientific, Agilent, Shimadzu, and CTC instruments.

 

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GC Ferrules and Connectors

Conveniently assembled fittings and tubing designed for reliable connections in your gas chromatography system.

 

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GC Tools, Tubing and Gas Flow Meters and Detectors

Conveniently assembled tools and tubing for use with your gas chromatography system.

 

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GC Reagents

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Making the undetectable, detectable

Improve separation and detectability of a compound destined for GC or GC-MS analysis using this selection of derivatization reagents. We also offer siliconizing fluids to coat various lab consumables with an inert, water-repellent film. All Thermo Scientific™ GC reagents offer the variety, quality and reliability you need. See below: 

Workflows


More

For environmental scientists pursuing lower detection limits and higher robustness in their analysis, selecting the correct workflow is imperative for success in delivering high-quality results.

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For food and beverage scientists pursuing higher quality analysis as well as higher throughput in their analysis, selecting the correct workflow can be imperative for success.

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Sample Handling


The Thermo Scientific sample handling portfolio contains the most comprehensive selection of vials and closures, from microsampling to headspace, to match all of your application and autosampler requirements. Improve sample security and integrity with the Thermo Scientific™ AVCS™ 9mm closures and SureStop™ 9mm screw top vial range. Our vials and closures offer you assurance of uninterrupted productivity on every separation and analysis procedure.

SureStop™ Vials and AVCS Closures

When used together, SureStop™ Vials and AVCS Closures significantly reduce the error rate of analysis that results from evaporation of solvent in vials that are not sealed correctly.

WebSeal™ Well Plates & Mats

A comprehensive range of well plate products for high-density sample handling in chromatography.

Microsample Spring Inserts

See why an autosampler glass vial insert with a spring is by far the better option for small sample volumes.


Consumables Overview



More

Preventing sample failures for bioanalysis.

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SOLA-Brochure-2021.pdf
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5 MB
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Maximize GC and GC-MS system performances, minimize system downtime and troubleshooting.

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Thermo-Scientific-Routine-GC-Maintenance-Rreference-Schedule.pdf
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132 KB
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SMART Digest delivers simple, robust, reproducible and fast digestion of proteins.

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SMART-Digest-Kit-Technical-Guide.pdf
Size
3 MB
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application/pdf

CDS for your chromatography and routine mass spectroscopy instruments.

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Thermo-Scientific-DNAPac-Family-of-Columns.pdf
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3 MB
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Fast, easy and cost-effective, QuEChERS is a robust, reproducible approach for extracting and cleaning up pesticides and other low-level contaminants in complex matrices.

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QuEChERS.pdf
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6 MB
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Experience expanded column capabilities with a diverse Thermo Scientific™ preparative HPLC column portfolio which offers uncompromising performance for all your scale up needs.

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The high quality Thermo Scientific™ Titan3™ and Target2™ syringe filters ensure reliable elimination of both particles and micro organisms in the sample preparation process, providing consistent and reliable experimental results for a range of samples and applications.

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Thermo-Scientific-Titan3-and-Target2-Chromatography-Syringe-Filters.pdf
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3 MB
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Thermo Scientific UHPLC-MS reverse-phase solvents provide consistent, ultrapure quality for your discovery-driving results.

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