Epredia™ Lab Vision™ Amyloid A4/Amyloid β Ab-1, Mouse Monoclonal Antibody

Description

Amyloid beta-protein/amyloid A4 or amyloid beta-peptide is derived from the amyloid beta-precursor protein. Beta amyloid is an extracellular filamentous protein deposit found in the brain. It is the major protein component of amyloid cores, neuritic plaques and is also found as a deposit in neurofibrillary tangles. In humans, Alzheimer's disease is the most common cause of senile dementia and is characterized by abnormal filamentous protein deposits in the brain. Beta amyloid deposits are also detected in Lewy body dementia, Down's syndrome, amyloidosis (Dutch type) and in the Guam Parkinson-Dementia complex.

Host Species: Mouse

Clone: BAM01; same as 6F/3D

Isotype: IgG1/κ

Species Reactivity: Human. Others not tested.

Epitope: aa 8-17 (SGYEVHHQKL) of mature amyloid A4/ amyloid Beta which is the same as aa 660-669 of human amyloid A4/amyloid β protein precursor

Immunogen: A synthetic peptide consisting of residues 8-17 (SGYEVHHQKL) of the amyloid β-protein/amyloid A4 which is the same as aa 660-669 of human amyloid A4/amyloid β protein precursor

Molecular Weight: 102kDa (precursor), 4-5kDa (mature)

Positive Control: Human brain of Alzheimer's disease

Cellular Localization: Transmembrane (APP) and extracellular (Amyloid β)

Recommended for:

• Immunohistochemistry (Formalin/paraffin only)

Note:

USA: RUO; Int'l: RUO