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activin A receptor, type IB, Mouse, Clone: 1C1, Abnova™

Mouse monoclonal antibody raised against a partial recombinant ACVR1B.

Brand:  Abnova H00000091-M09.100ug

Product Code. 16144334

  • 349.00€ / 100µg

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Description

Description

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed. [provided by RefSeq

Sequence: SGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLDGMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPVE
Specifications

Specifications

activin A receptor, type IB
Monoclonal
Unconjugated
PBS with no preservative; pH 7.4
BC000254
ACVR1B
ACVR1B (AAH00254, 24 a.a. ∼ 126 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
100 μg
Kinases
Primary
Human
Antibody
ELISA, In situ PLA, Western Blot
1C1
Mouse monoclonal antibody raised against a partial recombinant ACVR1B.
ACVR1B
ACTRIB/ACVRLK4/ALK4/SKR2
Mouse
Affinity Purified
RUO
Yes
91
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
IgG1 κ
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