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Description
The 4E2 monoclonal antibody specifically binds to CD121b which is also known as the IL-1 receptor type II (IL-1RII, IL-1R2) or IL-1 receptor beta (IL-1R-beta, IL-1Rβ). CD121b is encoded by the Il1r2 gene and presents as a 68 kDa type I transmembrane glycoprotein. It is expressed on a variety of cell types including B cells, neutrophils, monocytes, and bone marrow progenitor cells. A soluble form of CD121b is produced by proteolysis especially after cellular activation. Unlike the IL-1 type I receptor (CD121a), CD121b has a short cytoplasmic domain and does not mediate IL-1 signaling. CD121b may function in a membrane or soluble form as a decoy receptor that can bind IL-1 and reduce its effective concentration and biological activity. The 4E2 antibody blocks IL-1 binding to the IL-1 receptor type II.
Specifications
| CD121b | |
| Monoclonal | |
| 0.2mg/mL | |
| Il1r2; IL-1RII; IL-1R2; Il1rb; IL-1Rβ; IL-1R-beta; IL-1 receptor beta chain | |
| Rat | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
| Flow Cytometry | |
| 4.00E+02 | |
| PE | |
| Aqueous buffered solution containing ≤0.09% sodium azide. | |
| Mouse IL-1RII Protein | |
| 0.2 mg | |
| Immunology | |
| Mouse | |
| IgG2a κ |
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