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p67 (phox) Mouse, Unlabeled, Clone: 29, BD
Mouse Monoclonal Antibody
186.18€ - 330.63€
Specifications
| Antigen | p67 (phox) |
|---|---|
| Clone | 29 |
| Concentration | 250μg/mL |
| Applications | Western Blot |
| Classification | Monoclonal |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
15875699
|
BD Biosciences
610912 |
50 μg |
 187.00€ 186.18€ / 1 set Save 0.82€ 0.44% Off |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
|
15885699
|
BD Biosciences
610913 |
150 μg |
332.00€ 330.63€ / 1 set Save 1.37€ 0.41% Off |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
Description
The neutrophil respiratory burst oxidase (NADPH-oxidase) generates superoxide and secondary oxygen-derived toxic products in response to bacteria or a variety of soluble stimuli. The active site of this enzyme is located in an integral membrane cytochrome, b558, that consists of the two subunits gp91 [phox] and p21 [phox]. Superoxide production depends on the formation of a complex that includes p67 [phox], p47 [phox], and the GTP-binding protein Rac. Upon activation, these proteins translocate from the cytosol to the membrane where they assemble with b558 and induce oxidase activity. p67 [phox] contains two SH3 domains and binds, via its C-terminal SH3 domain, to the proline rich
region of p47 [phox]. This binding allows p67 [phox] to indirectly associate with the oxidase. It is thought that the phosphorylated forms of p67 [phox] and p47 [phox] interact and that the phosphorylation of p67 [phox] is regulated by both PKC-dependent and independent pathways. Although the role of p67 [phox] in electron flow control is poorly understood, it is thought that it regulates the transfer of electrons from NADPH to reduce flavin.
Immunofluorescence, Western Blotting
Specifications
| p67 (phox) | |
| 250μg/mL | |
| Monoclonal | |
| Mouse | |
| Cell Biology | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| IgG2b | |
| Affinity Purified |
| 29 | |
| Western Blot | |
| Unconjugated | |
| RUO | |
| Human, Mouse | |
| Human p67 [phox] aa. 317-469 | |
| Primary | |
| Store undiluted at -20°C. |
For Research Use Only.
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