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runt-related transcription factor 2, Mouse, Clone: 4D5, Abnova™

Mouse monoclonal antibody raised against a partial recombinant RUNX2.

Brand:  Abnova H00000860-M04.100ug

Product Code. 16073725

  • 365.00€ / 100µg

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Description

Description

This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq

Sequence: NPRPSLNSAPSPFNPQGQSQITDPRQAQSSPPWSYDQSYPSYLSQMTSPSIHSTTPLSSTRGTGLPAITDVPRRISDDDTATSDFCLWPSTLSKKSQAGA
Specifications

Specifications

runt-related transcription factor 2
Monoclonal
Unconjugated
PBS with no preservative; pH 7.4
NM_004348
RUNX2
RUNX2 (NP_004339, 251 a.a. ∼ 350 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
100 μg
Transcription Regulation
Primary
Human, Rat
Antibody
ELISA, Immunofluorescence, Immunohistochemistry (PFA fixed), Western Blot
4D5
Mouse monoclonal antibody raised against a partial recombinant RUNX2.
RUNX2
AML3/CBFA1/CCD/CCD1/MGC120022/MGC120023/OSF2/PEA2aA/PEBP2A1/PEBP2A2/PEBP2aA/PEBP2aA1
Mouse
Affinity Purified
RUO
Yes
860
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
IgG2a κ
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