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INAVA Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Thermo Scientific PA555635
Additional Details : Weight : 0.02000kg
Description
Immunogen sequence: PPQTLEGLQP TGPEAGSPER APVQNSPWKE TSLDHPYEKP RKSSEPWSES SSPATTPQDG PSASSLWLLE PASYHVVPIR G Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 81%.
Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (PubMed:28436939). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation (PubMed:29420262). [UniProt]Specifications
INAVA | |
Polyclonal | |
Unconjugated | |
C1orf106 | |
1700034M08Rik; 4933426C09Rik; 5730559C18Rik; AI586180; C1orf106; chromosome 1 open reading frame 106; D1Mgi54; Inava; Innate immunity activator protein; RGD1311892; RIKEN cDNA 5730559C18 gene; similar to hypothetical protein FLJ10901; uncharacterized protein C1orf106; uncharacterized protein C1orf106 homolog | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
55765 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Western Blot | |
0.2 mg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
Q3KP66 | |
C1orf106 | |
Recombinant protein corresponding to Human C1orf106 | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Research Use Only