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Invitrogen™ Carbonic Anhydrase IX Chimeric Recombinant Mouse Monoclonal Antibody (M75)
Mouse Recombinant Monoclonal Antibody
Brand: Invitrogen™ MA551609
This item is not returnable.
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Description
This antibody is specific for the sequence PGEEDLP, which is repeated several times between the 61st and 96th aa residues of human carbonic anhydrase IX's PG domain.
Carbonic anhydrase (CA) is an enzyme that assists rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. It is abundant in all mammalian tissues. There are many genes that are inducible by hypoxia, via HIF-1 alpha. CA IX is one of the most inducible genes because of its stability and location within the membrane. Carbonic anhydrases have a widespread role in regulating pH in normal tissues, by regulating hydrogen ion (H+) flux. The pH is important in cell death under hypoxia, thus a blockade of CA IX results in increased cell death under hypoxia. Therefore, CA IX has become a reliable histochemical marker of hypoxia.
Specifications
| Carbonic Anhydrase IX Chimeric | |
| Recombinant Monoclonal | |
| 1 mg/mL | |
| PBS with 0.02% ProClin 300 | |
| Q16790 | |
| CA9 | |
| The original antibody was generated by immunizing BALB/C mice with MaTu-infected HeLa cells (sequence PGEEDLP). | |
| 200 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 κ |
| ELISA, Immunohistochemistry (Paraffin), Western Blot, Western Blot | |
| M75 | |
| Unconjugated | |
| CA9 | |
| Ca9; CA-9; CAIX; CA-IX; Car9; Carbonate dehydratase IX; carbonic anhydrase 9; Carbonic anhydrase IX; carbonic dehydratase; G250; Membrane antigen MN; membrane antigen MN homolog; MN; MN/CA9; P54 / 58N; P54/58N; pMW1; RCC-associated antigen G250; RCC-associated protein G250; renal cell carcinoma-associated antigen G250 | |
| Mouse | |
| Protein A | |
| RUO | |
| 768 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
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