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CD122 Monoclonal Antibody (5H4), Biotin, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
106.00€ - 301.00€
Specifications
Antigen | CD122 |
---|---|
Clone | 5H4 |
Concentration | 0.5 mg/mL |
Applications | Flow Cytometry |
Classification | Monoclonal |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15279699
|
Affymetrix eBioscience
13-1221-81 |
50 μg |
106.00€
50µg |
Estimated Shipment: 11-06-2024 Log in to see stock. |
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15289699
|
Affymetrix eBioscience
13-1221-82 |
100 μg |
200.00€
100µg |
Estimated Shipment: 11-06-2024 Log in to see stock. |
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15299699
|
Affymetrix eBioscience
13-1221-85 |
500 μg |
This item has been discontinued and is no longer available. View the product for possible alternatives or contact our Technical Support team on 056 260 260 for assistance. |
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Description
Description: The 5H4 antibody reacts with mouse CD122, the 90-110 kDa interleukin-2 receptor beta chain. CD122 is expressed by NK cells and some T cells in the periphery and is upregulated by activation. CD122 associates with CD25 and CD132 (common gamma chain) to form the high affinity IL-2 receptor. Binding of IL-2 to CD122 is not inhibited by the 5H4 antibody. Applications Reported: The 5H4 antibody has been reported for use in flow cytometric analysis. Applications Tested: The 5H4 antibody has been tested by flow cytometric analysis of resting and activated mouse splenocytes. This can be used at less than or equal to 0.25 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Filtration: 0.2 μm post-manufacturing filtered.
CD122 (Interleukin 2 receptor) is involved in T cell-mediated immune responses, primarily expressed in the hematopoietic system and is present in 3 forms. The low affinity form of CD122 is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from CD122. The protein encoded by the CD122 gene represents the beta subunit and is a type I membrane protein. Diseases associate with CD122 protein dysfunction include oligoarticular juvenile idiopathic arthritis and rheumatoid factor negative juvenile idiopathic arthritis.Specifications
CD122 | |
0.5 mg/mL | |
Monoclonal | |
Liquid | |
RUO | |
P16297 | |
Il2rb | |
Primary | |
4° C, store in dark, DO NOT FREEZE! | |
Il2rb |
5H4 | |
Flow Cytometry | |
Biotin | |
Rat | |
Mouse | |
16185 | |
IgG2a κ | |
Affinity chromatography | |
Antibody |
For Research Use Only.