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  6. CD217 (IL-17Ra) Monoclonal Antibody (424LTS), Functional Grade, eBioscience™, Invitrogen™
  7. 17181552

CD217 (IL-17Ra) Monoclonal Antibody (424LTS), Functional Grade, eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 16-7917-38

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Product Code. 17181552

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Description

Description

The 424LTS monoclonal antibody reacts with and blocks IL-17A binding to human interleukin 17 receptor A (IL-17RA, IL-17R). IL-17RA is a type I membrane protein of approximately 96 kDa (866 amino acids) and is involved in inflammatory responses to IL-17A, IL-17F and IL-17AF heterodimer. It forms heterodimeric complexes with several other members of its receptor family, including IL-17RC for IL-17A and IL-17F signaling and IL-17RC for IL-17E (IL-25) signaling. IL-17RA is ubiquitously expressed, but in leukocytes its expression is elevated on granulocytes and monocytes. Applications Reported: This 424LTS antibody has been reported for use in blocking IL-17 receptor A ligand binding. Applications Tested: The ND50 of 424LTS as measured by the inhibition of IL-6 induction in NHDF cells is 1-5 μg/mL in the presence of 3 ng/mL of recombinant Human IL-17A. Neutralization dose will vary depending on assay method, cytokine concentration, and cell type. This antibody should be carefully titrated for optimal performance in the assay of interest. Storage and handling: Use in a sterile environment. Filtration: 0.2 μm post-manufacturing filtered. Purity: Greater than 90%, as determined by SDS-PAGE. Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by LAL assay. Aggregation: Less than 10%, as determined by HPLC.

CD217 (IL-17Ra) Monoclonal antibody specifically detects CD217 (IL-17Ra) in Human samples. It is validated for Functional Assay, Neutralization
TRUSTED_SUSTAINABILITY
Specifications

Specifications

CD217 (IL-17Ra)
Monoclonal
1 mg/mL
PBS with no preservative; pH 7.2
Q96F46
Mouse
5 mg
Primary
Human
Antibody
IgG1 κ
Functional Assay, Neutralization
424LTS
Functional Grade
Il17ra
AW538159; CANDF5; CD127; CD217; CDw217; hIL-17R; IL-17 receptor A; Il17r; Il17ra; IL-17RA; interleukin 17 receptor A; interleukin-17 receptor A; MGC10262; VDw217
Affinity chromatography
RUO
23765
4° C
Liquid
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