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CD25 Rat, anti-Mouse, PE, Clone: 3C7, STEMCELL Technologies
Rat Monoclonal Antibody
Brand: Stemcell Technologies 60010PE
This item is not returnable.
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Description
- The 3C7 antibody reacts with murine CD25 (interleukin‐2 receptor α chain; IL‐2Rα), an ∼55 kDa type 1 transmembrane glycoprotein expressed on the surface of T and B cell progenitors and activated mature B and T cells
- CD25 has been used as a marker to identify CD4+/FoxP3+ regulatory T cells in mice
- Mutations in CD25 result in severe immunodeficiency, underscoring the importance of the roles the protein plays in the differentiation, activation and proliferation of lymphocytes, and in the maintenance of self-tolerance
- CD25 per se has low affinity for its IL-2 ligand but forms dimers with CD122 (IL-2Rβ) and CD132 (IL-2Rγ) that together associate to form the IL-2R receptor, which binds IL-2 with high affinity
- CD25 acts to increase the specificity and affinity of IL-2 binding and is necessary for receptor clustering and signal transduction by the complex
- Binding of the 3C7 antibody inhibits binding of IL‐2 to free CD25 and the IL-2R receptor
- The epitope is distinct from those recognized by the anti-CD25 antibody clones 7D4 and PC61
Specifications
| CD25 | |
| Monoclonal | |
| PE | |
| 100 μg | |
| Mouse | |
| T Cells, T Cells, Regulatory |
| CyTOF, Flow Cytometry, Functional Assay, Immunohistochemistry | |
| 3C7 | |
| Rat | |
| Primary | |
| IgG2b κ |
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