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CD3 Mouse, anti-Human, APC, Clone: OKT3, STEMCELL Technologies
Mouse Monoclonal Antibody
176.85€ - 405.00€
Specifications
| Antigen | CD3 |
|---|---|
| Clone | OKT3 |
| Applications | Immunohistochemistry, Western Blot, Flow Cytometry, Functional Assay |
| Classification | Monoclonal |
| Conjugate | APC |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
17107521
|
Stemcell Technologies
100-0288 |
25 Tests |
176.85€
25 tests |
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|
17117521
|
Stemcell Technologies
100-0289 |
100 Tests |
405.00€
100 tests |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
Description
- The OKT3 antibody reacts with an extracellular conformational epitope on the ∼20 kDa CD3ε subunit of the human T cell receptor (TCR)/CD3 complex, which is expressed on the surface of ∼95% of mature T cells and NKT cells, and variably on thymocytes
- A majority of T cell neoplasms also express CD3
- CD3 is a dimer assembled from combinations of CD3γ, δ, ε, η, and ζ subunits, which are structurally related type 1 transmembrane proteins and members of the immunoglobulin superfamily
- CD3 associates non-covalently with the TCR and is involved in transducing antigen recognition signals into the cytoplasm of T cells and in regulating T cell activation and the expression of the TCR on the cell surface
- Mutations in CD3 have been associated with disorders of the immune system, including severe combined immunodeficiency (SCID)
- The OKT3 antibody recognizes an epitope that is expressed when the CD3ε subunit associates with either CD3γ or CD3δ, and binding of the antibody can induce T cell activation
- Because of its immunosuppressive properties in vivo, the OKT3 antibody has proven useful in treating allograft rejection
- Clone OKT3 is widely used for phenotyping human T cells, and it has been observed to block the binding of anti-CD3 antibody clones SK7 and UCHT1
Specifications
| CD3 | |
| Immunohistochemistry, Western Blot, Flow Cytometry, Functional Assay | |
| APC | |
| Human |
| OKT3 | |
| Monoclonal | |
| Mouse | |
| Primary |
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