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CD3 Mouse, anti-Human, PerCP, Clone: UCHT1, STEMCELL Technologies
Mouse Monoclonal Antibody
Brand: Stemcell Technologies 60011PR.1
This item is not returnable.
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Description
- The UCHT1 antibody reacts with the ∼20 kDa CD3ε subunit of the human T cell receptor (TCR)/CD3 complex, which is expressed on the surface of ∼95% of mature T cells and NKT cells, and variably onthymocytes
- A majority of T cell neoplasms also express CD3
- The CD3 complex, which is assembled from combinations of CD3γ, δ, ε, η, and ζ subunits, associates non-covalently with the TCR and is involved in transducing antigen recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR
- Activation of T cells by the TCR involves the cytoplasmic tails of the CD3 subunits, which are structurally related type 1 transmembrane proteins and members of the immunoglobulin superfamily
- Mutations in the CD3 subunits have been associated with various immunodeficiency disorders including severe combined immunodeficiency (SCID)
Specifications
| CD3 | |
| Monoclonal | |
| PerCP | |
| 25 Tests | |
| Chimpanzee, Human | |
| T Cells |
| Immunohistochemistry, Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence | |
| UCHT1 | |
| Mouse | |
| Primary | |
| IgG1 κ |
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