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CD4 Rat anti-Mouse, APC-Cy7, Clone: GK1.5, BD
Rat Monoclonal Antibody
Brand: BD Biosciences 552051
This item is not returnable.
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Description
The GK1.5 monoclonal antibody specifically binds to the mouse CD4 (L3T4) differentiation antigen. CD4 is expressed on most thymocytes, a subpopulation of mature T lymphocytes (i.e., MHC class II-restricted T cells, including most T helper cells), and a subset of NK-T cells. In addition, CD4 has also been reported to be detectable on pluripotent hematopoietic stem cells, bone marrow myeloid and B-lymphocyte precursors, intrathymic lymphoid precursors, and a subset of splenic dendritic cells. CD4 has also been reported to be expressed on the plasma membrane of mouse egg cells and is involved in adhesion of the egg to MHC class II-bearing sperm. CD4 is an antigen coreceptor on the T-cell surface which interacts with MHC class II molecules on antigen-presenting cells. It participates in T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase lck. The GK1.5 antibody reportedly blocks binding of the RM4-5 and H129.19, but not RM4-4 mouse CD4-specific antibodies.
Specifications
| CD4 | |
| Monoclonal | |
| 0.2mg/mL | |
| Cd4; CD4 antigen; L3T4; Ly-4; T-cell surface antigen T4/Leu-3 | |
| Rat | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
| Flow Cytometry | |
| GK1.5 | |
| APC-Cyanine7 | |
| Aqueous buffered solution containing ≤0.09% sodium azide. | |
| Mouse CTL clone V4 | |
| 0.1 mg | |
| Immunology | |
| Mouse | |
| IgG2b κ |
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