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  7. 17179121

CD40 Mouse, anti-Human, APC, Clone: 5C3, STEMCELL Technologies

Mouse Monoclonal Antibody

Brand:  Stemcell Technologies 60113AZ.1

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Product Code. 17179121

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Description

Description

  • The 5C3 antibody reacts with CD40, a 45 - 50 kDa type I transmembrane glycoprotein that is a member of the tumor necrosis factor receptor (TNFR) superfamily
  • CD40 plays an important role in B cell development and is also involved in the process of B cell selection in germinal centers
  • It facilitates T cell-B cell interactions for co-stimulation and immune regulation through engagement with CD154 (gp39), the CD40 ligand expressed on T cells
  • In the presence of IL-4, or other stimuli, CD40 promotes B cell proliferation, induces immunoglobulin- (Ig) isotype class switching and rescues B cells from surface Ig-induced apoptosis
  • CD40 is expressed on the surface of B cells, follicular dendritic cells, macrophages, fibroblasts, keratinocytes, endothelial cells, basal epithelial cells, CD34+ hematopoietic progenitor cells, and primary carcinomas
  • It is expressed at low levels, or not at all, on plasma cells
  • The 5C3 antibody has been used for the activation of B cells in in vitro functional assays or for the induction of B cell proliferation
Specifications

Specifications

CD40
Monoclonal
APC
25 Tests
Baboon, Cynomolgus, Rhesus Monkey, Chimpanzee, Human
B Cells
Immunohistochemistry, Flow Cytometry, Functional Assay
5C3
Mouse
Primary
IgG1 κ
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