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CD45.2 Mouse anti-Mouse, PE, Clone: 104, eBioscience™

Mouse Monoclonal Antibody

107.00€ - 265.00€

Specifications

Antigen CD45.2
Clone 104
Target Species Mouse
Conjugate PE
Isotype IgG2a, kappa
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Products 3
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15258549
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Affymetrix eBioscience
12-0454-81
50 μg 107.00€
50µg View alternative products
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Estimated Shipment
14-09-2020
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15268549
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Affymetrix eBioscience
12-0454-82
100 μg 168.00€
100µg View alternative products
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Estimated Shipment
18-08-2020
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15278549
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Affymetrix eBioscience
12-0454-83
200 μg 265.00€
200µg View alternative products
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In stock, ready to ship: 9
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Description

Description

CD45.2 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45.2 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45.2 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides the role in immunoreceptor signaling, CD45.2 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells.
Specifications

Specifications

CD45.2
Mouse
IgG2a, kappa
Monoclonal
Liquid
Antibody
4° C, store in dark, DO NOT FREEZE!
104
PE
Flow Cytometry
Primary
Monoclonal
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
RUO

For Research Use Only.