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CD49b (Integrin alpha 2) Monoclonal Antibody (DX5), Biotin, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
89.00€ - 298.00€
Specifications
Antigen | CD49b (Integrin alpha 2) |
---|---|
Clone | DX5 |
Concentration | 0.5 mg/mL |
Applications | Flow Cytometry |
Classification | Monoclonal |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15289959
|
Affymetrix eBioscience
13-5971-82 |
100 μg |
198.00€
100µg |
In Stock Log in to see stock. |
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15299959
|
Affymetrix eBioscience
13-5971-85 |
500 μg |
298.00€
500µg |
Estimated Shipment: 05-06-2024 Log in to see stock. |
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15279959
|
Affymetrix eBioscience
13-5971-81 |
50 μg |
This item has been discontinued and is no longer available. View the product for possible alternatives or contact our Technical Support team on 056 260 260 for assistance. |
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Description
Description: The DX5 monoclonal antibody reacts with CD49b, an antigen expressed on a majority of mouse natural killer cells and a subset of T cells. DX5 reacts with all strains of mouse tested including the most commonly used strains, BALB/c, C57BL/6, C3H, CBA, DBA, AKR, SJL and 129. Simultaneous staining of C57BL/6 spleen cells with anti-NK1.1 mAb (PK136) and DX5 reveals coexpression of both markers by a majority of cells as well as presence of small populations of DX5+PK136- and DX5-PK136+ cells. Applications Reported: The DX5 antibody has been reported for use in flow cytometric analysis. Applications Tested: The DX5 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.25 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Filtration: 0.2 μm post-manufacturing filtered.
CD49b (Integrin alpha 2, Integrin alpha 2 chain, VLA-2 alpha chain, HM alpha 2) is a member of the integrin family. It is a glycoprotein with molecular weight of 150 kD, and it complexes with CD29 (Integrin beta 1) to form the heterodimeric integrin VLA-2 (integrin alpha 2 beta 1, or GPIa/IIa) complex. VLA-2 is an extracellular receptor for laminin, collagen, and fibronectin, and interaction with its ligands results in the activation of intracellular signaling pathways. It has reported roles in VEGF-induced angiogenesis in vivo, as well as adhesion and lymphocyte activation. CD49b is expressed by NK cells, NK-T cells, monocytes, platelets, and epithelial cells. It is also expressed on adaptive immune cells such as T and B cells, specifically on a subset of CD4+ T cells in the spleen, on intraepithelial and lamina propria lymphocytes in the intestine, as well as on a population of peripheral CD4+ type 1 T regulatory (Tr1) cells that co-express LAG-3.Specifications
CD49b (Integrin alpha 2) | |
0.5 mg/mL | |
Monoclonal | |
Liquid | |
RUO | |
Q62469 | |
Itga2 | |
Primary | |
4° C, store in dark, DO NOT FREEZE! | |
Itga2 |
DX5 | |
Flow Cytometry | |
Biotin | |
Rat | |
Mouse | |
16398 | |
IgM κ | |
Affinity chromatography | |
Antibody |
For Research Use Only.