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  6. CD6 Monoclonal Antibody (IM348), eBioscience™, Invitrogen™
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CD6 Monoclonal Antibody (IM348), eBioscience™, Invitrogen™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-0061-95

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Product Code. 17150412

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Description

Description

The MAb IM348 recognizes mouse CD6, a transmembrane glycoprotein of the scavenger receptor family. The extracellular domain contains three scavenger receptor cysteine rich (SRCR) domains, a transmembrane region and a cytoplasmic domain of variable length depending on the isoform. CD6 is expressed on most T lymphocytes. Expression between human and mouse is slightly different. In mice B cells in the spleen do not have CD6, while humans express it on a subset of B lymphocytes. The CD6 ligand is CD166, also known as Activated Leukocyte Cell Adhesion Molecule (ALCAM). Through interactions with CD166 or homotypic CD6-CD6, a role exists in adhesion and migration during organogenesis. The intracellular domain of CD6 is constitutively phosphorylated, suggesting a role in T cell activation and signaling. In humans depletion of CD6-expressing cells increases graft versus host tolerance in transplants.

CD6 Monoclonal antibody specifically detects CD6 in Mouse samples. It is validated for Flow Cytometry, Immunohistochemistry (Frozen), Western Blot
TRUSTED_SUSTAINABILITY
Specifications

Specifications

CD6
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q61003
Rat
10 mg
Primary
Mouse
Antibody
IgG2a
Flow Cytometry, Immunohistochemistry (Frozen), Western Blot
IM348
Unconjugated
CD6
CD6; CD6 antigen; CD6 antigen, Tp120; CD6 molecule; FLJ44171; OX52; Soluble CD6; T12; T-cell differentiation antigen CD6; TP120
Affinity chromatography
RUO
12511
4° C
Liquid
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