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CD83 Mouse, anti-Human, Biotin, Clone: HB15e, STEMCELL Technologies
Mouse Monoclonal Antibody
POA
Specifications
| Antigen | CD83 |
|---|---|
| Clone | HB15e |
| Applications | Immunoblot, Flow Cytometry, Immunohistochemistry |
| Classification | Monoclonal |
| Conjugate | Biotin |
Description
- The HB15e antibody reacts with CD83, an ∼45 kDa type I transmembrane glycoprotein and member of the Siglec protein family, containing an extracellular V-type Ig-like domain and a C-terminal cytoplasmic tail
- A soluble form of CD83 has also been identified
- CD83 is expressed predominantly on circulating and tissue dendritic cells, including Langerhan cells and interdigitating reticulum cells
- It is expressed weakly on activated lymphocytes and may also be found on neutrophils, monocytes and macrophages
- Expression of CD83 is typically transient, except on dendritic cells, and correlates with upregulation of HLA class II antigen
- Its function, though ill-defined, is essential for the development and maintenance of the immune system and evidence suggests it may be involved in cell adhesion and signaling, antigen presentation, and lymphocyte activation
- The epitope on CD83 bound by the HB15e antibody reportedly overlaps with that of antibody 1E11
Specifications
| CD83 | |
| Immunoblot, Flow Cytometry, Immunohistochemistry | |
| Biotin | |
| Baboon, Cynomolgus, Rhesus Monkey, Chimpanzee, Human | |
| Primary |
| HB15e | |
| Monoclonal | |
| Mouse | |
| IgG1 κ |
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