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Invitrogen™ Human CDK13/cyclin K, GST Tag, His Tag Recombinant Protein

Product Code. p-7180889
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15960413 10 μg 10µg
17108825 100 μg 100µg
17148845 1 mg 1mg
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Product Code. 15960413 Supplier Invitrogen™ Supplier No. A33510

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Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. This CDK13/cyclin K recombinant human protein (CDK13: 656-1050, cyclin K 1-300) was expressed in insect cells. CDK13/cyclin K recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service. Validated for use with the LanthaScreen™ Eu Kinase Binding assay Available in multiple pack sizes for convenient use Also available in our SelectScreen Kinase Profiling Service Protein Form: Recombinant, Active, Catalytic The gene accession number for CDK13 and cyclin K are NP_003709.3 and NP_001092872.1.

Cyclin-dependent kinase 13 (CDK13) and Cyclin K form a complex that is integral to RNA processing and transcription regulation. CDK13, a member of the CDK family, is involved in the modulation of gene expression through phosphorylation of the C-terminal domain of RNA Polymerase II, affecting the transcription elongation phase. Cyclin K acts as a regulatory partner to CDK13, stabilizing its active conformation to efficiently catalyze its kinase functions. CDK13, along with Cyclin K, plays a pivotal role in RNA metabolism, influencing RNA splicing and 3' end processing, which are crucial for the synthesis of mature mRNA. Structural studies have characterized CDK13 as having unique features differentiating it from other CDKs, including distinctive domain arrangements that enable interaction with Cyclin K. The dysregulation of CDK13/Cyclin K activity has been observed in various diseases, including cancer, pointing to their importance as therapeutic targets. Research also highlights CDK13's involvement in maintaining cellular homeostasis, underscoring the complex network of interactions this kinase engages in beyond transcriptional control.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number O75909, Q14004
Concentration See Label
For Use With (Application) Kinase Assay
Formulation 50mM HEPES with 15mM glutathione, 5mM DTT, 100mM NaCl, 20% glycerol and no preservative; pH 7.5
Gene ID (Entrez) 8621, 8812
Molecular Weight (g/mol) 73.8-63.0 kDa
Name Human CDK13/cyclin K, GST Tag, His Tag
pH Range 7.5
Purification Method Purified
Quantity 10 μg
Storage Requirements -80°C, Avoid Freeze/Thaw Cycles
Regulatory Status RUO
Gene Alias 2310015O17Rik; CDC2L; Cdc2l5; CDC2-related protein kinase 5; CDK13; cell division cycle 2-like 5 (cholinesterase-related cell division controller); cell division cycle 2-like protein kinase 5; Cell division protein kinase 13; CHED; Cholinesterase-related cell division controller; cyclin dependent kinase 13; cyclin-dependent kinase 13; hCDK13; Kiaa1791
Common Name CDK13/cyclin K
Gene Symbol CCNK, CDK13
KinaseFamily CDKs and CHKs
Product Type Protein
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag GST-tag, His-tag
Sequence CDK13: 656 -1050, Cyclin K: 1-300
Content And Storage -80°C, Avoid Freeze/Thaw Cycles
Shipping Condition Dry Ice
Expression System Insect cells
Protein Family Kinases & Inhibitors
Protein Form Recombinant, Active, Catalytic
Form Liquid
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