Learn More
CLAC-P Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA14306
Additional Details : Weight : 0.01000kg
Description
PA1-4306 detects CLAC-P (NC2-1 region) in human and mouse samples. PA1-4306 has been successfully used in Western blot procedures. By Western blot this antibody detects bands of 50, 70, and 100 kDa representing CLAC-P in formic acid extracts of Alzheimer’s disease brain. PA1-4306 immunizing peptide corresponds to amino acid residues 171-183 of the NC2-1 region of human and mouse CLAC-P.
Alzheimer’s disease (AD) is characterized by deposition of beta-amyloid as senile plaques and cerebral amyloid angiopathy. The principal component of AD amyloid is the amyloid beta peptide (A beta). Although production and deposition of A beta appear closely related to the pathogenesis of AD, current evidence suggest that A beta alone is not sufficient to cause neuronal death and symptoms of dementia. A component of senile plaque (SP), CLAC (collagen-like Alzheimer amyloid plaque component ) and its precursor CLAC-P are deposited with extracellular beta-amyloid and have been recently implicated in cell toxicity of beta-amyloid in AD brains. CLAC-P is a unique, membrane-bound collagen-like structure containing three Gly-X-Y repeat motifs and may define a novel class of neuronal collagens.Specifications
CLAC-P | |
Polyclonal | |
Unconjugated | |
COL25A1 | |
2700062B08Rik; Alzheimer disease amyloid-associated protein; AMY; CFEOM5; CLAC; CLACP; CLAC-P; Col25a1; collagen alpha-1(XXV) chain; collagen type XXV alpha 1; collagen, type XXV, alpha 1; collagen-like Alzheimer amyloid plaque component; collagenous Alzheimer amyloid plaque component; procollagen, type XXV, alpha 1 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
77018, 84570 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Liquid |
Western Blot | |
1 mg/mL | |
PBS with 0.02% sodium azide | |
Q99MQ5, Q9BXS0 | |
COL25A1 | |
Synthetic peptide: N(171) H G F L S A D Q QL I K(183) | |
100 μg | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |