missing translation for 'onlineSavingsMsg'
Learn More
Learn More
Invitrogen™ Cyclin E Recombinant Rabbit Monoclonal Antibody (24GB4745)

Rabbit Recombinant Monoclonal Antibody
Brand: Invitrogen™ MA557371
This item is not returnable.
View return policy
Description
Cyclin E Recombinant Monoclonal Antibody for Western Blot, ICC/IF, Flow
Cyclin E belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclin E forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available.
Specifications
| Cyclin E | |
| Recombinant Monoclonal | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| P24864 | |
| CCNE1 | |
| A synthesized peptide derived from human Cyclin E1 (aa 393-410). | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
| Flow Cytometry, Western Blot, Immunocytochemistry | |
| 24GB4745 | |
| Unconjugated | |
| CCNE1 | |
| AW538188; Ccne; Ccne1; CycE1; CYCLE; cyclin E; cyclin E1; cyclin Es; cyclin Et; E-S; G1/S-specific cyclin-E1; pCCNE1 | |
| Rabbit | |
| Affinity chromatography | |
| RUO | |
| 898 | |
| -20°C | |
| Liquid |
Berichtigung von Produktinhalten
Bitte geben Sie uns Ihr Feedback zu den Produktinhalten, indem Sie das folgende Formular ausfüllen.
Name des Produkts
Haben Sie Verbesserungsvorschläge?Übermitteln Sie eine inhaltliche Korrektur