missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. Tocris Bioscience™ DBZ

Tocris Bioscience™ DBZ
GREENER_CHOICE

Product Code. 18710688
Change view
Click to view available options
Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
2 product options available for selection
Product selection table with 2 available options. Use arrow keys to navigate and Enter or Space to select.
Product Code. Quantity unitSize
18710688 10 mg 10mg
18724957 50 mg 50mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 2 options available.
2 options
This item is not returnable. View return policy
Product Code. 18710688 Supplier Tocris Bioscience™ Supplier No. 4489/10

Please to purchase this item. Need a web account? Register with us today!

305.20 EUR valid until 2026-03-31
BEST PRICE on Promo! Use promo code "27931" to get your promotional price.
Denna artikel kan inte returneras. Se returpolicy

Beskrivning

γ-secretase inhibitor; inhibits Notch pathway

DBZ is an inhibitor of γ-secretase aspartyl protease. DBZ blocks amyloid precursor protein-like (APPL) and Notch cleavage (IC50 values are 2.6 nM and 1.7-2.9 nM, respectively). By inhibiting Notch and the Notch pathway, DBZ improves efficiency of iPSC generation and production of iPSCs from mouse and human keratinocytes without KLF4 and CMYC. In an animal model of Alzheimer's disease, DBZ inhibits the cleavage of amyloid precursor protein into Aβ40. DBZ promotes cochlear supporting cell proliferation and hair cell mitotic regeneration in neonatal mice. DBZ in combination with iDOT1L enables maintenance of human na?ve-state pluripotency in non-hypoxic conditions.

DBZ synthesized to Ancillary Material Grade also available.

TRUSTED_SUSTAINABILITY

Specifikationer

Chemical Name or Material DBZ
CAS 209984-56-5
Assay Percent Range >98%
Quantity 10 mg
Molecular Formula C26H23F2N3O3
Formula Weight 463.48
Produkttitel
Välj ett problem

Genom att klicka på Skicka bekräftar du att du kan bli kontaktad av Fisher Scientific angående feedbacken du har lämnat i detta formulär. Vi kommer inte att dela din information för andra ändamål. All kontaktinformation som tillhandahålls ska också underhållas i enlighet med vår Sekretesspolicy.