Invitrogen™ Decapentaplegic Monoclonal Antibody (146609)

Description

Reconstitute at 0.5 mg/mL in sterile PBS.

Decapentaplegic (Dpp) is a gene in Drosophila melanogaster, encoding a protein that is a member of the Transforming Growth Factor-beta (TGF-beta) superfamily. Dpp plays a crucial role in various developmental processes, including embryogenesis, organogenesis, and the regulation of cell growth and differentiation. It functions primarily as a morphogen, a signaling molecule that forms a concentration gradient to provide positional information to cells, guiding their development and differentiation. Dpp is essential for the proper patterning of tissues and organs, such as the wings, legs, and gut in fruit flies. Mutations in the Dpp gene can lead to severe developmental abnormalities and defects in tissue patterning. The study of Dpp and its signaling pathways provides valuable insights into the mechanisms of morphogen-mediated development and has broader implications for understanding similar TGF-beta signaling pathways in other organisms, including humans.