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  5. Tocris Bioscience™ Dimethylenastron

Tocris Bioscience™ Dimethylenastron
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Product Code. 18750268
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18750268 50 mg 50mg
18773168 10 mg 10mg
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Product Code. 18750268 Supplier Tocris Bioscience™ Supplier No. 5261/50

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Description

Inhibitor of mitotic motor kinesin Eg5

Dimethylenastron is an inhibitor of mitotic motor kinesin Eg5 (IC50 = 200 nM). Arrests mitosis, triggers apoptosis and up-regulates Hsp-70 expression in multiple human myeloma cell lines. Also inhibits the growth of several types of cancer cell lines (EC50 values are 330, 603, 743 and 881 nM in HCT116, Htert-HME1, BxPC3, K562 and NCI-H1299 cancer cells, respectively). Suppresses the migration and invasion of PANC1 cells in vitro. Cytoprotective.
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Specifications

Chemical Name or Material 2,3,4,6,7,8-Hexahydro-4-(3-hydroxyphenyl)-7,7-dimethyl-2-thioxo-5(1H)-quinazolinone
CAS 863774-58-7
Quantity 50 mg
Target Kinesin Inhibitors
Molecular Formula C16H18N2O2S
Formula Weight 302.39
Purity >99%
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