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Invitrogen™ DMPK Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ 349900

Product Code. 10415833

  • 516.00€ / 50µg

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Description

Description

DMPK Polyclonal Antibody for Western Blot, ICC/IF, ELISA

DMPK is a serine/threonine kinase expressed in various muscle and nerve tissues. Mutations in the untranslated region of the DMPK gene are a characteristic of myotonic dystrophy. The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-37 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

DMPK
Polyclonal
Unconjugated
DMPK
DM; DM protein kinase; DM1; DM1 protein kinase; Dm15; DM1PK; DMK; DM-kinase; Dmpk; dystrophia myotonica kinase, B15; dystrophia myotonica protein kinase; dystrophia myotonica-protein kinase; MDPK; MT-PK; myotonic dystrophy associated protein kinase; myotonic dystrophy protein kinase; myotonin protein kinase A; myotonin-protein kinase; thymopoietin homolog
Rabbit
Antigen affinity chromatography
RUO
13400
-20°C
Liquid
ELISA, Western Blot, Immunocytochemistry
0.25 mg/mL
PBS with 0.1% sodium azide; pH 7.4
P54265
DMPK
Synthetic peptide from the C-terminal region of the mouse Myotonic Dystrophy Protein kinase (DMPK) protein.
50 μg
Primary
Mouse
Antibody
IgG
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