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Docetaxel, 99%

Product Code. 15452989
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Product Code. 15452989 Supplier Thermo Scientific Alfa Aesar Supplier No. J60174.03
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Description

Docetaxel, CAS # 114977-28-5, is a cytotoxic, semisynthetic, second-generation taxane derived from the needles of the European yew tree and displays antineoplastic, antibiotic, and antimicrotubule activities. | CAS: 114977-28-5 | C43H53NO14 | 807.89 g/mol

Docetaxel is a second-generation cytotoxic antimicrotubule agent and is mostly used in the pharmaceutical industry.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Docetaxel is an analog of taxol, and is considered to be a cytotoxic, semisynthetic, second-generation taxane that exhibits antineoplastic, antibiotic, and antimicrotubule activities
• Docetaxel is capable of inhibiting cellular mitosis. This compound promotes the assembly of microtubules from tubulin dimers and stabilizes microtubules by preventing depolymerization. This stability inhibits the normal dynamic reorganization of the microtubule network that is essential for vital interphase and mitotic cellular functions. This results in the persistence of abnormal microtubule structures leading to cell-cycle arrest and cell death

Application

• Docetaxel can inhibit angiogenesis by acting on vascular endothelial growth factor (VEGF) associated with cancer cells
• This compound has been used to investigate the effect of lysosomal autophagic flux in gastric cancer cells

TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 114977-28-5
Molecular Formula C43H53NO14
Molecular Weight (g/mol) 807.89
MDL Number MFCD00800737
InChI Key ZDZOTLJHXYCWBA-VCVYQWHSSA-N
Synonym docetaxel, taxotere, docetaxel anhydrous, docetaxol, emdoc, docetaxel, trihydrate, docetaxel inn, taxotere tn, unii-699121phca, txl
PubChem CID 148124
ChEBI CHEBI:4672
SMILES CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O

Specifications

Melting Point 186°C to 192°C
Color White
Quantity 1 g
Merck Index 14,3397
Solubility Information Soluble in dimethyl sulfoxide and ethanol; Insoluble in water.
Formula Weight 807.88
Percent Purity 99%
Physical Form Powder
Chemical Name or Material Docetaxel

RUO – Research Use Only

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