Invitrogen™ Factor VIII Monoclonal Antibody (F8-2.2.32), Invitrogen™

Description

MA1-10588 detects full-length human Factor VIII. This antibody does not cross-react with von Willebrand factor. MA1-10588 has been successfully used in ELISA and Western blot applications. The MA1-10588 immunogen is purified human Factor VIII.

This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.