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Invitrogen™ Factor X/Xa Monoclonal Antibody (9050)
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Product Code. 11529882
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Quantity:
100 μg
Unit Size:
100µg
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11529882 100 μg 100µg
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Product Code. 11529882 Supplier Invitrogen™ Supplier No. MA143035

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Description

Rat Monoclonal Antibody

This antibody detects mouse factor X (heavy chain) and mouse factor Xa (heavy chain) by ELISA and Western blot, and cross-reacts with human factor X/Xa (Western blot only). Western blot can be performed under reducing and non-reducing conditions. Inhibitory properties: Does not inhibit PT (mouse plasma). Purity >95% by SDS-PAGE.

Factor X undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Factor X/Xa
Applications ELISA, Western Blot
Classification Monoclonal
Clone 9050
Concentration 8 mg/mL
Conjugate Unconjugated
Formulation 50% water with 50% glycerol and no preservative
Gene F10
Gene Accession No. O88947, P00742
Gene Alias Activated factor Xa heavy chain; blood coagulation factor X; Cf10; coagulation factor 10; coagulation factor X; coagulation factor X protein; F10; Factor X heavy chain; Factor X light chain; factor Xa; FX; FXA; prothrombinase; stuart factor; Stuart-Prower factor; Unknown (protein for IMAGE:8121240); unnamed protein product
Gene Symbols F10
Host Species Rat
Immunogen Purified mouse factor X.
Purification Method SDS-PAGE
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14058, 2159
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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