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Fluconazole, 99%

Product Code. 15454479
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Product Code. 15454479 Supplier Thermo Scientific Alfa Aesar Supplier No. J62015.03
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Description

Fluconazole, CAS # 86386-73-4, is a synthetic triazole with antifungal activity against some species of Candida. It also shows inhibitory activity against cytochrome P-450 enzymes and it is a demethylase. | CAS: 86386-73-4 | C13H12F2N6O | 306.277 g/mol

Fluconazole is used to treat a variety of fungal infections, especially Candida infections of the vagina (yeast infections), mouth, throat and bloodstream. It is also used by the people having weak immune system such as persons with neutropenia due to cancer chemotherapy, transplanted patients and premature infants.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Fluconazole, 98% is a triazole compound showing antifungal activity mainly against Candida, Coccidioides, and Cryptococcus species
  • It has been shown to inhibit fungal cytochrome P-450 sterol C-14 α-demethylation, resulting in the accumulation of fungal 14 α-methyl sterols, the loss of normal fungal sterols, and associated fungistatic activity
  • It also inhibits cytochrome P450 family 2 subfamily c member 9 (CYP2C9)
  • Mammalian cell demethylation is much less susceptible to fluconazole inhibition

Applications

  • Fluconazole has fungistatic activity against many fungal strains including Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis, and Cryptococcus neoformans.
  • Fluconazole interferes with fungal ergosterol synthesis and downregulates the metallothionein gene
  • In biological experiments, this compound has been used to assess minimum inhibitory concentration in (MIC)-fungal assays
  • It has also been used as a positive control in antifungal assay of plants
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 86386-73-4
Molecular Formula C13H12F2N6O
Molecular Weight (g/mol) 306.277
MDL Number MFCD00274549
InChI Key RFHAOTPXVQNOHP-UHFFFAOYSA-N
Synonym fluconazole, diflucan, triflucan, elazor, biozolene, biocanol, fungata, fluconazol, fluconazolum, flucazol
PubChem CID 3365
ChEBI CHEBI:46081
IUPAC Name 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol
SMILES C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O

Specifications

Melting Point 138°C to 140°C
Color White
Density 1.05
Quantity 1 g
Merck Index 14,4122
Solubility Information Soluble indimethylsulfoxide and ethanol.
Formula Weight 306.27
Percent Purity 99%
Physical Form Crystalline Powder
Chemical Name or Material Fluconazole

Safety and Handling

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Product Identifier
  • Fluconazole
 Signal Word
  • Danger
 Hazard Category
  • Acute toxicity Category 4
  • Serious eye damage/eye irritation Category 2
  • Reproductive toxicity Category 1B
  • Skin corrosion/irritation Category 2
  • Specific target organ toxicity Category 2
 Hazard Statement
  • H302-Harmful if swallowed.
  • H315-Causes skin irritation.
  • H319-Causes serious eye irritation.
  • H360D-May damage the unborn child.
  • H371-May cause damage to organs.
 Precautionary Statement
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
  • P302+P352-IF ON SKIN: Wash with plenty of water/soap.
  • P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P312-Call a POISON CENTER/doctor/if you feel unwell.
 Supplemental information
  • MIXTURE LIST-Contain: Fluconazole
SDS

RUO – Research Use Only

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