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  5. STEMCELL Technologies Fumonisin B1

STEMCELL Technologies Fumonisin B1

Product Code. 17140262
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Product Code. 17140262 Supplier STEMCELL Technologies Supplier No. 73684

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Description

Inhibitor of sphingolipid synthesis and protein serine/threonine phosphatases

  • Fumonisin B1 is a mycotoxin produced by Fusarium moniliforme that has been shown to potently inhibit sphingosine N-acyltransferase (ceramide synthase; Wang et al.), thereby disrupting the synthesis of sphingolipids, a key component of plasma membranes (IC50 = 0.1 μM)
  • Fumonisin B1 also inhibits protein serine/threonine phosphatases (PPs; PP1, PP2A, PP2B, PP2C, and PP5/T/K/H) with IC50 values of 80 - 3000 μM
  • PP5 is the most sensitive with an IC50 of 80 μM (Fukuda et al.) Fumonisin B1, together with aflatoxin B1, increases reactive oxygen species levels and oxidative damage in rat spleen cells (Mary et al.)

Specifications

CAS 116355-83-0
Quantity 10 mg
Molecular Formula C34H59NO15
Purity ≥95%
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