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Invitrogen™ GABBR1 Recombinant Rabbit Monoclonal Antibody (JE60-09)
Rabbit Recombinant Monoclonal Antibody
Brand: Invitrogen™ MA550825
This item is not returnable.
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Description
Positive control: K-562 cell lysate, Jurkat cell lysate, HeLa cell lysate, SHG-44 cell lysate, mouse brain tissue. Predicted band size: 108 kDa Subcellular Location: Cell membrane, Postsynaptic cell membrane, Cell projection, dendrite; Secreted.
Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
Specifications
| GABBR1 | |
| Recombinant Monoclonal | |
| 1 mg/mL | |
| PBS with 0.05% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4 | |
| Q9UBS5, Q9WV18 | |
| GABBR1 | |
| Recombinant protein within Human GABA B Receptor 1 aa 35-134/961. | |
| 100 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |
| Immunohistochemistry (Paraffin), Western Blot | |
| JE60-09 | |
| Unconjugated | |
| GABBR1 | |
| bM573K1.1; bM573K1.1.1 (gamma-aminobutyric acid (GABA) B receptor, 1a); DAAP-188P13.3; dJ271M21.1.1; dJ271M21.1.2; FLJ92613; GABA(B) receptor; GABAB; GABA-B receptor 1; GABA-B receptor, R1 subunit; GABAB1; Gaba-b1; GABAbR1; GABA-BR1; GABA-B-R1; Gababr1 receptor; Gaba-b-r1a; Gaba-br1a receptor; GABA-BR1b receptor; Gabbr1; GABBR1-3; gamma-aminobutyric acid; gamma-aminobutyric acid (GABA) B receptor 1; gamma-aminobutyric acid (GABA) B receptor, 1; gamma-aminobutyric acid (GABA-B) receptor, 1; gamma-aminobutyric acid type B receptor subunit 1; GB1; GBR1; GPRC3A; HGB1a; OTTHUMP00000109099; OTTHUMP00000214725; seven transmembrane helix receptor | |
| Rabbit | |
| Protein A | |
| RUO | |
| 2550, 54393 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
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