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GM-CSF Rat anti-Mouse, Biotin, Clone: MP1-31G6, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 13-7332-81

Additional Details : Poids : 0.25000kg

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Product Code. 15380060

  • 94.50€ / 50µg


Expédition estimée
08-10-2020
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Description

Description

GM-CSF (Granulocyte-Macrophage colony-stimulating factor) is a 14.6kDa hematopoietic growth factor that exists in glycosylated and non-glycosylated biologically active forms, and stimulates the development of granulocytes, macrophages, early megakaryocytes and eosinophil progenitor cells. The active form of the GM-CSF protein is found extracellularly as a homodimer and the GM-CSF gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q-syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. The ability of recombit GM-CSF to increase hematopoietic cell recovery has become a focus area in the therapeutic treatment of patients following bone marrow transplantation. Recent studies have investigated GM-CSF in inflammatory and autoimmune diseases such as arthritis, arthritis related interstitial lung disease, nephritis, and psoriasis. In the CNS, GM-CSF depletion or neutralization has been studied in experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS).
Specifications

Specifications

GM-CSF
Monoclonal
0.5 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
P01587
Granulocyte Macrophage Colony Stimulating Factor, Colony-stimulating factor, CSF, Sargramostim, Molgramostin
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
ELISA
MP1-31G6
Biotin
Csf2
Liquid
Csf2
IgG1, kappa
50 μg
4° C, do not freeze
Primary
12981
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For Research Use Only.